Perfluorooctanoic Acid (PFOA) Exposures and Incident Cancers among Adults Living Near a Chemical Plant

http://dx.doi.org/10.1289/ehp.1306615



Table 5. HRs (95% CIs) by PFOA quartilea for thyroid, kidney, and testicular cancer cases among the cohort (n = 32,254).
Cancer No. of casesb Quartile 1 (reference) Quartile 2 Quartile 3 Quartile 4 p-Valuec p-Valued
aQuartiles were defined by the estimated cumulative PFOA serum concentration among the thyroid, kidney, or testicular cancer cases at the time of cancer diagnosis. bA proportional hazards regression model was run for each cancer; each model was adjusted for time-varying smoking, time-varying alcohol consumption, sex, education, and stratified by 5-year period of birth year. Time began at age 20 years if the person’s 20th birthday was in 1952 or later; otherwise time began at the age the person was in 1952; time ended at the age of cancer diagnosis, age at the last follow-up survey, or age on December 31st 2011, whichever came first. cp-Value is for linear trend test in the log rate ratios across quartiles; p-Values were calculated using exposure category midpoints and inverse variance weighting in a no-intercept linear regression model. dp-Value is from the continuous log estimated cumulative PFOA serum concentration models.
Kidney              
No lag 105 1.00 1.23 (0.70, 2.17) 1.48 (0.84, 2.60) 1.58 (0.88, 2.84) 0.18 0.10
10-year lag 105 1.00 0.99 (0.53, 1.85) 1.69 (0.93, 3.07) 1.43 (0.76, 2.69) 0.34 0.15
Testes              
No lag 17 1.00 1.04 (0.26, 4.22) 1.91 (0.47, 7.75) 3.17 (0.75, 13.45) 0.04 0.05
10-year lag 17 1.00 0.87 (0.15, 4.88) 1.08 (0.20, 5.90) 2.36 (0.41, 13.65) 0.02 0.10
Thyroid              
No lag 86 1.00 1.54 (0.77, 3.12) 1.48 (0.74, 2.93) 1.73 (0.85, 3.54) 0.25 0.20
10-year lag 86 1.00 2.06 (0.93, 4.56) 2.02 (0.90, 4.52) 1.51 (0.67, 3.39) 0.57 0.65