Fetal Growth and Prenatal Exposure to Bisphenol A: The Generation R Study

http://dx.doi.org/10.1289/ehp.1205296



Table 4. Linear regression analyses for repeated measurements of the association between BPA during pregnancy and fetal growth rates according to the number of urine samples analyzed.
Samples/women (µg/g crea)   No. of women Fetal weight
β (95% CI)
Fetal head circumference β (95% CI)
Abbreviations: BPACB, creatinine-based total BPA concentration; crea, creatinine. Beta coefficient represents the average decrease in SD of fetal weight per gestational week. Adjusted for maternal age, educational level, ethnicity, parity, smoking during pregnancy, alcohol use during pregnancy, height at intake, weight before pregnancy, folic acid supplement use, and sex.
*p < 0.05. **p < 0.10.
Three samples   80    
BPACB < 1.54   Reference Reference
BPACB 1.54 < BPACB < 2.51   –0.041 (–0.081, –0.001)* –0.052 (–0.098, –0.006)*
BPACB 2.51 < BPACB < 4.22   –0.043 (–0.082, –0.004)* –0.046 (–0.090, –0.003)*
BPACB > 4.22   –0.029 (–0.070, 0.012) –0.066 (–0.113, –0.019)*
BPACB Per unit increase in BPACB   –0.017 (–0.033, –0.001)* –0.018 (–0.037, 0.000)**
Two samples   120    
BPACB < 1.54   Reference Reference
BPACB 1.54 < BPACB < 2.51   –0.018 (–0.045, 0.009) –0.018 (–0.055, 0.018)
BPACB 2.51 < BPACB < 4.22   –0.029 (–0.056, –0.003)* –0.013 (–0.049, 0.022)
BPACB > 4.22   –0.003 (–0.033, 0.027) –0.017 (–0.057, 0.023)
BPACB Per unit increase in BPACB   –0.008 (–0.024, 0.008) –0.005 (–0.024, 0.013)
One sample   219    
BPACB < 1.54   Reference Reference
BPACB 1.54 < BPACB < 2.51   0.003 (–0.027, 0.032) –0.011 (–0.049, 0.025)
BPACB 2.51 < BPACB < 4.22   0.008 (–0.025, 0.040) 0.003 (–0.036, 0.041)
BPACB > 4.22   0.025 (–0.002, 0.052) 0.015 (–0.022, 0.051)
BPACB Per unit increase in BPACB   –0.007 (–0.023, 0.010) 0.011 (–0.008, 0.030)