Perfluorooctanoic Acid Exposure and Cancer Outcomes in a Contaminated Community: A Geographic Analysis

http://dx.doi.org/10.1289/ehp.1205829



Table 1. WV and OH water district results:n and AORs (95% CIs) for exposure to contaminated water districts.
Cancer outcome Total Total exposed Little Hocking Lubeck Tuppers Plains Belpre Pomeroy Mason
n n AOR (CI) n AOR (CI) n AOR (CI) n AOR (CI) n AOR (CI) n AOR (CI) n AOR (CI)
Adjusted for age, sex, diagnosis year, insurance provider, and smoking status; controls were other listed cancers excluding kidney, liver, pancreas, and testis cancers. Estimated 1995 median PFOA serum concentrations in the WDs: Little Hocking = 125 µg/L; Lubeck = 65.8 µg/L; Tupper Plains = 23.9 µg/L; Belpre = 18.7 µg/L; Pomeroy = 10.7 µg/L; and Mason = 5.3 µg/L; reference = unexposed.
Bladder 1,350 137 0.8 (0.7, 1.0) 7 0.6 (0.3, 1.4) 24 1.0 (0.6, 1.5) 20 0.9 (0.6, 1.5) 24 1.1 (0.7, 1.6) 4 0.8 (0.3, 2.1) 58 0.7 (0.6, 1.0)
Brain 506 60 1.0 (0.8, 1.3) 1 0.2 (0.0, 1.5) 7 0.8 (0.4, 1.8) 9 1.1 (0.5, 2.1) 11 1.2 (0.6, 2.2) 3 1.7 (0.5, 5.4) 29 1.1 (0.7, 1.6)
Female breast 4,057 436 1.0 (0.9, 1.1) 33 1.2 (0.8, 2.0) 69 1.2 (0.9, 1.7) 50 0.7 (0.5, 1.1) 73 1.1 (0.8, 1.5) 18 0.8 (0.5, 1.5) 193 1.0 (0.8, 1.2)
Cervix 338 35 0.8 (0.6, 1.2) 4 0.9 (0.3, 2.9) 5 0.7 (0.3, 1.7) 8 1.8 (0.8, 3.8) 5 0.6 (0.2, 1.6) 2 0.9 (0.2, 4.1) 11 0.7 (0.4, 1.3)
Colon/rectum 3,543 383 0.9 (0.8, 1.0) 20 0.7 (0.5, 1.2) 44 0.7 (0.5, 1.0) 66 1.2 (0.9, 1.6) 55 0.9 (0.7, 1.2) 18 1.2 (0.7, 2.1) 180 0.9 (0.8, 1.1)
Kidney 751 94 1.1 (0.9, 1.4) 10 1.7 (0.9, 3.3) 9 0.7 (0.4, 1.3) 23 2.0 (1.3, 3.1) 17 1.4 (0.8, 2.3) 0 35 0.9 (0.6, 1.3)
Leukemia 674 72 0.9 (0.7, 1.1) 5 1.0 (0.4, 2.3) 11 0.9 (0.5, 1.6) 9 0.8 (0.4, 1.7) 12 1.0 (0.6, 1.9) 1 0.4 (0.1, 2.8) 34 0.9 (0.6, 1.3)
Liver 179 23 1.1 (0.7, 1.6) 1 0.8 (0.1, 5.6) 4 1.3 (0.5, 3.5) 3 1.0 (0.3, 3.3) 3 1.0 (0.3, 3.1) 1 1.4 (0.2, 10.5) 11 1.0 (0.5, 1.9)
Lung 4,926 632 1.2 (1.1, 1.3) 37 1.0 (0.7, 1.5) 85 1.1 (0.8, 1.4) 84 1.3 (1.0, 1.7) 90 1.1 (0.9, 1.4) 23 1.1 (0.7, 1.8) 313 1.3 (1.1, 1.5)
Melanoma of the skin 1,428 168 0.9 (0.8, 1.1) 12 1.0 (0.6, 1.9) 32 1.2 (0.8, 1.7) 21 0.9 (0.6, 1.4) 38 1.4 (1.0, 2.0) 4 0.9 (0.3, 2.5) 61 0.7 (0.5, 0.9)
Multiple myeloma 285 36 1.1 (0.8, 1.6) 1 0.5 (0.1, 3.6) 4 0.9 (0.3, 2.3) 3 0.7 (0.2, 2.2) 7 1.5 (0.7, 3.2) 1 0.9 (0.1, 6.6) 20 1.4 (0.9, 2.2)
Non-Hodgkin lymphoma 1,124 152 1.2 (1.0, 1.5) 14 1.6 (0.9, 2.8) 20 1.1 (0.7, 1.7) 21 1.2 (0.8, 1.9) 24 1.3 (0.9, 2.0) 5 1.1 (0.4, 2.7) 68 1.2 (0.9, 1.5)
Ovary 417 48 1.0 (0.8, 1.4) 5 1.8 (0.7, 4.4) 5 0.7 (0.3, 1.7) 6 1.1 (0.5, 2.4) 11 1.6 (0.9, 3.0) 2 1.1 (0.3, 4.4) 19 0.9 (0.5, 1.4)
Pancreas 495 58 1.0 (0.8, 1.3) 4 1.1 (0.4, 3.0) 9 1.1 (0.6, 2.1) 10 1.3 (0.7, 2.5) 8 0.9 (0.4, 1.8) 2 1.0 (0.2, 4.1) 25 0.9 (0.6, 1.4)
Prostate 3,678 434 0.9 (0.8, 1.1) 36 1.4 (0.9, 2.3) 78 1.2 (0.9, 1.6) 56 0.8 (0.6, 1.1) 56 0.8 (0.6, 1.1) 12 1.3 (0.6, 2.6) 196 0.9 (0.7, 1.0)
Testis 134 18 1.0 (0.6, 1.8) 8 5.1 (1.6, 15.6) 2 0.9 (0.2, 4.5) 2 0.4 (0.1, 2.0) 1 0.6 (0.1, 5.0) 0 5 0.5 (0.2, 1.5)
Thyroid 343 40 1.1 (0.7, 1.5) 3 0.8 (0.3, 2.7) 7 1.2 (0.6, 2.6) 2 0.3 (0.1, 1.4) 5 0.9 (0.4, 2.2) 0 23 1.4 (0.9, 2.2)
Uterus 879 97 1.0 (0.8, 1.3) 7 1.1 (0.5, 2.4) 15 1.1 (0.6, 1.9) 12 0.9 (0.5, 1.6) 14 0.9 (0.5, 1.6) 4 0.9 (0.3, 2.4) 45 1.1 (0.8, 1.5)