Perfluorooctanoic Acid Exposure and Cancer Outcomes in a Contaminated Community: A Geographic Analysis

http://dx.doi.org/10.1289/ehp.1205829



Table 2. OH serum-level results:n and AORs (95% CIs) for individual-level annual PFOA serum exposure categories assuming 10-year residency and latency.
Cancer outcome Total Total exposed Very high High Medium Low
n n n AOR (CI) n AOR (CI) n AOR (CI) n AOR (CI)
Adjusted for age, race, sex, diagnosis year, insurance provider, and smoking status; controls were other listed cancers excluding kidney, liver, pancreas, and testis cancers. ­Categories of modeled PFOA serum concentrations: very high = 110–655 µg/L; high = 30.8–109 µg/L; medium = 12.9–30.7 µg/L; low = 3.7–12.8 µg/L; reference = unexposed.
Bladder 395 69 4 0.6 (0.2, 1.5) 21 1.2 (0.8, 2.0) 21 0.9 (0.6, 1.4) 23 0.9 (0.6, 1.4)
Brain 150 32 0 4 0.6 (0.2, 1.6) 16 1.8 (1.1, 3.2) 12 1.5 (0.8, 2.7)
Female breast 1,260 223 29 1.4 (0.9, 2.3) 45 0.7 (0.5, 1.0) 77 1.1 (0.8, 1.5) 72 0.9 (0.7, 1.2)
Cervix 144 25 2 0.6 (0.1, 2.6) 8 1.7 (0.8, 3.8) 4 0.5 (0.2, 1.5) 11 1.1 (0.6, 2.2)
Colon/rectum 1,149 212 13 0.6 (0.3, 1.0) 63 1.3 (1.0, 1.7) 64 0.9 (0.7, 1.2) 72 1.0 (0.8, 1.3)
Kidney 246 59 9 2.0 (1.0, 3.9) 22 2.0 (1.3, 3.2) 17 1.2 (0.7, 2.0) 11 0.8 (0.4, 1.5)
Leukemia 191 36 2 0.6 (0.1, 2.3) 8 0.9 (0.4, 1.8) 12 1.0 (0.6, 1.9) 14 1.2 (0.7, 2.1)
Liver 61 11 0 3 1.0 (0.3, 3.1) 4 0.9 (0.3, 2.5) 4 1.1 (0.4, 3.1)
Lung 1,526 293 29 1.0 (0.7, 1.6) 78 1.2 (0.9, 1.6) 95 1.0 (0.8, 1.3) 91 1.0 (0.7, 1.2)
Melanoma of the skin 429 95 9 0.9 (0.5, 1.9) 21 1.0 (0.6, 1.5) 38 1.3 (0.9, 1.8) 27 1.2 (0.8, 1.8)
Multiple myeloma 83 18 1 0.6 (0.1, 4.7) 4 1.0 (0.3, 2.7) 6 1.1 (0.5, 2.6) 7 1.4 (0.7, 3.2)
Non-Hodgkin lymphoma 347 76 11 1.8 (1.0, 3.4) 17 1.1 (0.7, 1.9) 28 1.5 (1.0, 2.2) 20 1.0 (0.6, 1.6)
Ovary 128 27 5 2.1 (0.8, 5.5) 8 1.4 (0.7, 2.9) 10 1.4 (0.7, 2.7) 4 0.5 (0.2, 1.4)
Pancreas 162 33 2 0.6 (0.1, 2.5) 9 1.1 (0.6, 2.3) 10 0.9 (0.5, 1.7) 12 1.3 (0.7, 2.3)
Prostate 1,155 214 31 1.5 (0.9, 2.5) 47 0.8 (0.5, 1.1) 65 0.8 (0.6, 1.0) 71 1.1 (0.8, 1.5)
Testis 61 11 6 2.8 (0.8, 9.2) 1 0.3 (0.0, 2.7) 3 0.6 (0.2, 2.2) 1 0.2 (0.0, 1.6)
Thyroid 94 15 2 0.8 (0.2, 3.5) 3 0.7 (0.2, 2.1) 5 0.9 (0.4, 2.3) 5 0.9 (0.4, 2.3)
Uterus 288 47 4 0.7 (0.3, 1.5) 12 1.7 (1.2, 2.5) 14 0.9 (0.6, 1.3) 17 1.2 (0.8, 1.7)