Exposure to Perfluoroalkyl Acids and Markers of Kidney Function among Children and Adolescents Living near a Chemical Plant

http://dx.doi.org/10.1289/ehp.1205838



Table 2. Associations between serum perfluoroalkyl acid (PFAA) concentrations and estimated glomerular filtration rate (eGFR).a
PFAA n IQR Model 1b Model 2c
Change in eGFR
(95% CI)c
p-Value Change in eGFR
(95% CI)c
p-Value
aExpressed as the mean change in eGFR per interquartile range (IQR) increase in each natural log-transformed PFAA.
bModel 1: adjusted for age, sex, race, smoking, and household income. cModel 2: adjusted for model 1 covariates plus regular exercise and BMI z-score. dFirst 10 years of life, or current age if < 10 years of age. eDuring 3 years before enrollment. fAt time of enrollment (2005–2006).
Measured            
PFOA 9,660 1.63 –0.75 (–1.41, –0.10) 0.02 –0.73 (–1.38, –0.08) 0.03
PFOS 9,660 0.64 –1.10 (–1.66, –0.53) 0.0001 –1.34 (–1.91, –0.77) < 0.0001
PFNA 9,660 0.51 –0.83 (–1.35, –0.30) 0.002 –0.88 (–1.41, –0.36) 0.001
PFHxS 9,660 1.27 –0.95 (–1.57, –0.32) 0.003 –1.02 (–1.64, –0.40) 0.001
Estimated PFOA            
Earlyd 4,787 2.10 –0.03 (–0.99, 0.93) 0.95 –0.09 (–1.04, 0.87) 0.86
Recente 6,060 1.88 –0.04 (–0.76, 0.68) 0.91 –0.06 (–0.77, 0.65) 0.87
Enrollmentf 6,060 1.84 –0.10 (–0.80, 0.60) 0.78 –0.12 (–0.81, 0.58) 0.75