High Bioavailability of Bisphenol A from Sublingual Exposure

http://dx.doi.org/10.1289/ehp.1206339



Table 1. Mean (± SD) values for pharmacokinetic parameters of BPA after iv, sublingual, and orogastric BPA dosing.
Pharmacokinetic parametera iv Sublingual Orogastric
0.05 mg/kg 5 mg/kg 0.05 mg/kg 5 mg/kg 20 mg/kg
Abbreviations: NA, not applicable; NC, not calculated.
aThe first 8 min following the end of sublingual adminis­tration were not taken into account in deriving the BPA pharmaco­kinetic parameters. *p ≤ 0.05, compared with iv administration of the same BPA dose by Student’s t-test.
Cmax (ng/mL) 64 ± 36 7,296 ± 1,615 249 ± 331 6,443 ± 3,910 47 ± 20
Tmax (min) 2 ± 0 3 ± 1 10 ± 4 13 ± 9 20 ± 8
AUClast (× 103 ng/min/mL) 1 ± 0 221 ± 54 2 ± 1 145 ± 44* 6 ± 2
MRT (min) NC 69 ± 13 NC 73 ± 33 112 ± 37
BPA bioavailability (%) NA NA NC 70 ± 31 0.72 ± 0.28