High Bioavailability of Bisphenol A from Sublingual Exposure

http://dx.doi.org/10.1289/ehp.1206339



Table 2. Mean (± SD) values for pharmacokinetic parameters of BPAG after iv, sublingual, and orogastric BPA dosing.
Pharmacokinetic parameter iv Sublingual Orogastric
0.05 mg/kg 5 mg/kg 0.05 mg/kg 5 mg/kg 20 mg/kg
Abbreviations: NA, not applicable; NC, not calculated.
*p ≤ 0.05, compared with iv administration of the same BPA dose by Student’s t-test.
Cmax (ng/mL) 78 ± 38 15,657 ± 6,426 46 ± 20* 11,808 ± 10,419 30,777 ± 13,604
Tmax (min) 12 ± 4 16 ± 7 35 ± 20 35 ± 13* 38 ± 18
AUClast (× 103 ng/min/mL) 8 ± 5 2,884 ± 776 7 ± 5 2,355 ± 893 6,081 ± 1,935
MRT (min) NC 417 ± 65 NC 562 ± 164 501 ± 200
BPA absorption and/or bioavailability (%) NA NA 90 ± 26 81 ± 18 54 ± 19