Ulcerative Colitis and Perfluorooctanoic Acid (PFOA) in a Highly Exposed Population of Community Residents and Workers in the Mid-Ohio Valley


Table 2. Numbers of participants with validated auto­immune diseases, mean age at diagnosis, and sex.a
Autoimmune disease No. self-reportedb No. validatedb Mean age Percent femalec
NA, not applicable.
aCases confirmed through medical records review. bIn the entire cohort, among people reporting diseases for which validation was sought, ~ 75% consented to medical record review, and among those who consented, a record was obtained for 92%; among these the percent validated across all diseases was 77%. For multiple sclerosis, rheuma­toid arthritis, and lupus, we included among the validated those cases which had been self-reported and not confirmed by us for lack of a medical record, but which had been confirmed previously during the C8HP (29, 19, and 5 cases respectively). For rheuma­toid arthritis, numbers are restricted to cases who reported taking medication; these were the only ones for which we sought medical records. c54% of the entire cohort was female. dIncludes cases self-reported as type 1 diabetes and then verified as either type 1 diabetes or insulin-dependent diabetes. eRestricted to the same self-reported cases specifically validated for type 1 diabetes.
Ulcerative colitis 596 151 44 59
Crohn’s disease 178 95 39 59
Rheumatoid arthritis 1,292 346 48 69
Type 1 diabetes–broadd 342 160 35 52
Type 1 diabetes–narrowe NA 85 27 48
Lupus 187 72 43 87
Multiple sclerosis 150 99 38 77