Design, Methods, and Population for a Study of PFOA Health Effects among Highly Exposed Mid-Ohio Valley Community Residents and Workers

http://dx.doi.org/10.1289/ehp.1206450



Table 1. Number of reported cases of adult chronic diseases, final combined cohort (n = 32,254).a
Condition No. of
self-reported cases
No. of self-reported cases for which a medical record was reviewed No. of
validated casesb
Percent validated
among reviewed
No. of validated cases available for prospective analysis
NA, not available.
aAnalyses of specific diseases reported elsewhere using these data may have applied exclusion criteria or specific case definitions that were different from those used here, leading to differences between numbers listed here and reported elsewhere. bValidation was through medical records review or registry matching (for cancer and chronic renal disease). Validation was not sought for osteoarthritis, hypertension, or high cholesterol. Among participants reporting diseases for which validation was sought, ~ 75% consented to medical record review; among those who consented, a record was obtained for 92%. cThe number of validated cancers available for prospective analysis varied by cancer type.
Osteoarthritis 6,641 NA NA NA 1,577
Rheumatoid arthritis with medication 1,292 943 317 34 56
Hypertension with medication 12,325 NA NA NA 2,319
High cholesterol with medication 9,909 NA NA NA 1,898
Coronary artery disease 3,147 2,754 2,502 91 541
Myocardial infarction 1,746 1,479 1,207 82 209
Stroke 1,596 1,245 913 73 269
Diabetes 5,141 4,488 3,651 81 929
Lupus 187 145 72 50 18
Multiple sclerosis 150 102 80 78 14
Thyroid disease with medication 3,027 2,321 2,108 91 467
Chronic kidney disease 725 557 433 78 169
Liver disease 1,896 1,251 715 57 267
Ulcerative colitis 596 419 151 36 29
Crohn’s disease 178 126 95 75 13
Parkinson’s disease 144 115 83 72 36
Chronic obstructive pulmonary disease 3,755 2,732 1,668 61 540
Asthma with medication 2,239 1,657 1,299 78 219
Malignancies (any of 21 sites) 3,292 2,555 2,361 92 c