Associations of Filaggrin Gene Loss-of-Function Variants with Urinary Phthalate Metabolites and Testicular Function in Young Danish Men

Table 1. “Parent” phthalate diesters to which humans are exposed, and their metabolites that are measurable in urine.
Phthalate group Parent phthalate diesters Measurable urinary metabolites LOD
Abbreviations: LMW, low-molecular-weight phthalates (often found in personal care products); HMW, high-molecular-weight phthalates (used as plasticizers; infrequently found in personal care products).
aMCPP is a metabolite of DOP, and is also a minor metabolite of diisooctyl phthalate, diisodecyl phthalate, DiNP, DEHP, BBzP and DBP (dibutyl phthalate).
LMW DEP Diethyl phthalate MEP Monoethyl phthalate 0.46
DnBP Di-n-butyl phthalate MnBP Mono-n-butyl phthalate 0.57
DiBP Diisobutyl phthalate MiBP Monoisobutyl phthalate 0.55
BBzP Butylbenzyl phthalate MBzP Monobenzyl phthalate 0.25
HMW DEHP Di(2-ethylhexyl) phthalate MEHP Mono(2-ethylhexyl) phthalate 0.63
MEHHP Mono(2-ethyl-5-hydroxyhexyl) phthalate 0.30
MEOHP Mono(2-ethyl-5-oxohexyl) phthalate 0.30
MECPP Mono(2-ethyl-5-carboxypentyl) phthalate 0.17
DOP Dioctyl phthalate MOP Mono-n-octyl phthalate 0.15
MCPPa Mono-3-carboxypropyl phthalate 0.14
DiNP Diisononyl phthalate MiNP Mono-isononyl phthalate 0.15
MHiNP Mono(hydroxy-isononyl) phthalate 0.12
MOiNP Mono(oxo-isononyl) phthalate 0.11
MCiOP Mono(carboxy-isononyl) phthalate 0.05