Associations of Filaggrin Gene Loss-of-Function Variants with Urinary Phthalate Metabolites and Testicular Function in Young Danish Men

http://dx.doi.org/10.1289/ehp.1306720



Table 4. Osmolality-adjusted urinary concentrations (ng/mL) of phthalate metabolites by FLG genotype, and estimated percentage difference between genotype groups, with corresponding p-values, from final multivariate regression models.
Phthalate group Phthalate metabolite Osmolality-adjusted median
(5th, 95th percentiles)
Estimated percent differencea (95% CI) p-Valuea
FLG-null FLG WT
All shown metabolites were detectable in urine in > 95% of participants, except MiNP (measurable in 49% of men). Abbreviations: LMW, low-molecular-weight phthalates often found in personal care products; HMW, high-molecular-weight phthalates used as plasticizers, infrequently found in personal care products.
aData are from multivariate linear regression models using ln-transformed phthalate metabolite concentrations, adjusting for age, smoking, and year of participation; adjusted means are provided in Figure 1.
LMW MEP 116 (18, 751) 83 (17, 2202) 0.4 (–39, 39) 0.9
MiBP 77 (31, 201) 61 (22, 171) 21 (4, 39) 0.02
MnBP 42 (14, 118) 29 (9, 89) 33 (16, 51) 0.0002
ΣDBP(i+n) 156 (65, 383) 117 (42, 319) 26 (9, 42) 0.003
MBzP 46 (14, 171) 37 (10, 157) 24 (0.2, 47) 0.05
HMW MEHP 5 (1, 15) 4 (0.5, 17) 13 (–12, 37) 0.3
MEHHP 29 (12, 79) 23 (8, 76) 16 (–5, 37) 0.1
MEOHP 19 (7, 45) 15 (4, 55) 20 (–1, 41) 0.06
MECPP 20 (7, 55) 16 (6, 53) 14 (–5, 33) 0.1
MiNP 0.7 (0.1, 4) 0.6 (0.1, 5) –3 (–36, 30) 0.8
MHiNP 6 (1, 26) 4 (0.9, 22) 25 (–2, 52) 0.07
MOiNP 3 (0.7, 13) 2 (0.4, 11) 26 (–4, 56) 0.09
MCiOP 8 (3, 55) 8 (3, 38) 14 (–7, 35) 0.2
ΣDEHPm 96 (37, 231) 80 (29, 271) 16 (–3, 35) 0.1
ΣDiNPm 24 (7, 154) 21 (6, 95) 16 (–6, 38) 0.2