Reducing Periconceptional Methylmercury Exposure: Cost–Utility Analysis for a Proposed Screening Program for Women Planning a Pregnancy in Ontario, Canada

http://dx.doi.org/10.1289/ehp.1409034



Table 4. Value of information analysis for screening intervention versus reference case.
Value of information WTP per QALY (Can$)
$20,000 $30,000 $50,000
Abbreviations: EVPI, expected value of perfect information; EVPPI, expected value of partial perfect information; Hg(B), blood mercury concentration; MMR, mild mental retardation (IQ between 50 and 70); QALY, quality-adjusted life year; WTP, willingness to pay. Percent of a standard deviation in cognitive deficits is used in the model used to quantify the loss in IQ points associated with a doubling of true prenatal mercury exposure. Disutility is defined as the loss in utility.
EVPI (Can$) 5.30 2.20 0.61
EVPPI (Can$)
Mean Hg(B) of women 20–39 years 1.41 0.02960 5.77E-06
Standard deviation Hg(B) of women 20–39 years 2.08 0.393 0.0463
Mean Hg(B) of women 40–49 years 0 0 0
Standard deviation Hg(B) of women 40–49 years 0 0 0
Ratio of cord/maternal Hg(B) 2.39 0.0606 0
Percent of a standard deviation in cognitive deficits 0.444 1.17E-05 0
Probability of a successful intervention 1.08 0.102 0.00509
Effectiveness of a successful intervention 1.24 0.0590 6.12E-04
Disutility for MMR 0.0404 0 0