Bisphenol S and F: A Systematic Review and Comparison of the Hormonal Activity of Bisphenol A Substitutes

http://dx.doi.org/10.1289/ehp.1408989



Table 3. Studies assessing BPS and BPF activity in vitro.
Study Chemical(s) tested End point measured Concentrations tested
CBA, competitive binding assay.
Audebert et al. 2011 BPF Cytotoxicity, genotoxicity 1 to 100 μM
Cabaton et al. 2006 BPF/BPS Antiandrogenicity, estrogenicity, genotoxicity

10–11 to 10–5 M and

36.4 to 170 μM

Chen et al. 2002 BPF/BPS Acute toxicity, estrogenicity 0.01 to 100 mg/L
Fic et al. 2013 BPF/BPS Cytotoxicity, genotoxicity, mutagenicity

12.5 to 100 μM,

0.1 to 10 μM, and

4 to 500 μg/plate

Grignard et al. 2012 BPS Estrogenicity 10–12 to 10–4 M
Hashimoto and Nakamura 2000 BPF/BPS Estrogenicity 10–7 to 10–3 M
Hashimoto et al. 2001 BPF/BPS Estrogenicity 10–9 to 10–3 M
Kidani et al. 2010 BPF Adiponectin 80 μM
Kitamura et al. 2003 BPF Estrogenic, estrogen CBA 10–8 to 10–4 M
Kitamura et al. 2005 BPF/BPS Antiandrogenicity, estrogenicity 10–7 to 10–4 M
Kuruto-Niwa et al. 2005 BPS Estrogenicity 10–7 to 10–4 M
Lee et al. 2013 BPF/BPS Cytotoxicity, genotoxicity 10 to 250 μM
Mathew et al. 2014 BPS Serum albumin binding 0.2 to 4 μM
Molina-Molina et al. 2013 BPF/BPS Androgenicity, antiandrogenicity, estrogenicity, estrogen CBA 10–8 to 10–5 M
Nakagawa and Tayama 2000 BPF Cytotoxicity, mitochondrial function 0.25 to 1 mM
Ogawa et al. 2006 BPF Estrogenicity 10–7 to 10–3 M
Perez et al. 1998 BPF Estrogenicity 10–8 to 10–5 M
Peyre et al. 2014 BPS Hepatic cell function 1 to 500 μM
Pisapia et al. 2012 BPF Estrogenicity 10–7 to 10–5 M
Rajasärkkä et al. 2014 BPF/BPS BPA activity, estrogenicity 10–7 to 10–2 M
Rosenmai et al. 2014 BPF/BPS Antiandrogenicity, estrogenicity, steroidogenesis, AhR activity 10–4 to 102 μM
Satoh et al. 2004 BPF Antiandrogenicity, cytotoxicity, estrogenicity, estrogen and androgen CBA 10–9 to 10–3 M
Stroheker et al. 2004 BPF Antiandrogenicity, antiestrogenicity, estrogenicity, estrogen CBA 10–10 to 10–5 M
Teng et al. 2013 BPS Androgenicity, estrogenicity 10–13 to 10–4 M
Viñas and Watson 2013a BPS Estrogenicity 10–15 to 10–7 M
Viñas and Watson 2013b BPS Estrogenicity 10–14 M
Yamasaki et al. 2004 BPS Estrogen CBA 10–11 to 10–4 M