Serum Testosterone Concentrations and Urinary Bisphenol A, Benzophenone-3, Triclosan, and Paraben Levels in Male and Female Children and Adolescents: NHANES 2011–2012

http://dx.doi.org/10.1289/EHP150



Table 2. Percent differences (95% CI) in serum total testosterone by quartiles of BP-3 exposure, National Health and Nutrition Examination Survey, 2011–2012.
BP-3 exposure Model 1a Model 2b
aAdjusted for age, race/ethnicity, serum cotinine, urinary creatinine, total cholesterol, income, obesity, season of collection, time of venipuncture, and physical activity (for adolescents only).
bAdjusted for model 1 covariates plus natural log–transformed BPA, TCS, and ∑PAR.
cp-Value for exposure quartiles modeled as an ordinal variable using integer values.
Male children
Q1: ≤ 3.5 ng/mL Reference Reference
Q2: 3.6–8.8 ng/mL –1.98 (–51.81, 97.39) 7.25 (–46.74, 115.98)
Q3: 8.9–71.1 ng/mL 27.12 (–20.55, 105.44) 31.00 (–25.17, 129.33)
Q4: > 71.7 ng/mL –1.98 (–44.57, 73.33) 4.08 (–40.55, 82.21)
p-Trendc 0.53 0.70
Male adolescents
Q1: ≤ 4.0 ng/mL Reference Reference
Q2: 4.1–15.9 ng/mL –7.69 (–43.45, 50.68) 1.01 (–34.30, 55.27)
Q3: 16.0–48.7 ng/mL –38.74 (–58.52, –10.42) –32.97 (–54.16, –1.98)
Q4: > 48.7 ng/mL –36.87 (–59.34, –1.98) –32.97 (–54.16, –0.50)
p-Trendc 0.01 0.04
Female children
Q1: ≤ 6.6 ng/mL Reference Reference
Q2: 6.7–13.9 ng/mL 10.52 (–19.75, 50.68) 7.25 (–31.61, 68.20)
Q3: 14.0–58.5 ng/mL 5.13 (–20.55, 39.10) –0.50 (–50.84, 101.38)
Q4: > 58.6 ng/mL 20.92 (–28.82, 105.44) 10.52 (–68.65, 293.54)
p-Trendc 0.87 0.91
Female adolescents
Q1: ≤ 8.6 ng/mL Reference Reference
Q2: 8.7–23.7 ng/mL 20.92 (3.05, 43.33) 17.35 (–1.00, 39.10)
Q3: 23.8–164.0 ng/mL 10.52 (–18.13, 49.18) 12.75 (–16.47, 50.68)
Q4: > 164.0 ng/mL 11.63 (–23.66, 64.87) 16.18 (–21.34, 71.60)
p-Trendc 0.14 0.27