Serum Testosterone Concentrations and Urinary Bisphenol A, Benzophenone-3, Triclosan, and Paraben Levels in Male and Female Children and Adolescents: NHANES 2011–2012

http://dx.doi.org/10.1289/EHP150



Table 3. Percent differences (95% CI) in serum total testosterone by quartiles of BPA exposure, National Health and Nutrition Examination Survey, 2011–2012.
BPA exposure Model 1a Model 2b
aAdjusted for age, race/ethnicity, serum cotinine, urinary creatinine, total cholesterol, income, obesity, season of collection, time of venipuncture, and physical activity (for adolescents only).
bAdjusted for model 1 covariates plus natural log–transformed BP-3, TCS, and ∑PAR.
cp-Value for exposure quartiles modeled as an ordinal variable using integer values.
Male children
Q1: ≤ 0.8 ng/mL Reference Reference
Q2: 0.9–1.5 ng/mL 16.18 (–44.01, 141.09) 9.42 (–46.74, 124.79)
Q3: 1.6–3.3 ng/mL –14.79 (–62.84, 95.42) –18.94 (–66.38, 93.48)
Q4: > 3.3 ng/mL –10.42 (–41.14, 37.71) –22.12 (–55.07, 34.99)
p-Trendc 0.27 0.19
Male adolescents
Q1: ≤ 0.9 ng/mL Reference Reference
Q2: 1.0–2.0 ng/mL –49.34 (–70.18, –13.06) –50.84 (–71.92, –13.93)
Q3: 2.1–3.7 ng/mL –36.87 (–62.47, 6.18) –38.12 (–63.21, 4.08)
Q4: > 3.7 ng/mL –53.70 (–70.77, –26.66) –52.29 (–71.35, –20.55)
p-Trendc 0.01 0.02
Female children
Q1: ≤ 0.7 ng/mL Reference Reference
Q2: 0.8–1.4 ng/mL 8.33 (–28.82, 64.87) 18.53 (–36.24, 118.15)
Q3: 1.5–2.8 ng/mL 8.33 (–30.93, 69.89) 19.72 (–42.88, 153.45)
Q4: > 2.8 ng/ mL 20.92 (–35.60, 127.05) 40.49 (–56.83, 352.67)
p-Trendc 0.86 0.94
Female adolescents
Q1: ≤ 0.7 ng/mL Reference Reference
Q2: 0.8–1.5 ng/mL 24.61 (–7.69, 69.89) 27.21 (–4.88, 71.60)
Q3: 1.6–3.2 ng/mL 39.10 (–4.88, 103.40) 36.34 (–6.76, 101.38)
Q4: > 3.2 ng/mL 53.73 (9.42, 113.83) 53.73 (12.75, 109.59)
p-Trendc 0.01 < 0.01