Serum Testosterone Concentrations and Urinary Bisphenol A, Benzophenone-3, Triclosan, and Paraben Levels in Male and Female Children and Adolescents: NHANES 2011–2012

http://dx.doi.org/10.1289/EHP150



Table 4. Percent differences (95% CI) in serum total testosterone by quartiles of TCS exposure, National Health and Nutrition Examination Survey, 2011–2012.
TCS exposure Model 1a Model 2b
aAdjusted for age, race/ethnicity, serum cotinine, urinary creatinine, total cholesterol, income, obesity, season of collection, time of venipuncture, and physical activity (for adolescents only).
bAdjusted for model 1 covariates plus natural log–transformed BP-3, BPA, and ∑PAR.
cp-Value for exposure quartiles modeled as an ordinal variable using integer values.
Male children
Q1: ≤ 2.5 ng/mL Reference Reference
Q2: 2.6–6.1 ng/mL –34.95 (–72.47, 53.73) –37.50 (–72.75, 41.91)
Q3: 6.2–18.1 ng/mL –15.63 (–63.58, 93.48) –17.30 (–62.09, 80.40)
Q4: > 8.1 ng/mL –10.42 (–52.29, 158.57) –16.18 (–51.32, 177.32)
p-Trendc 0.02 0.01
Male adolescents
Q1: ≤ 2.6 ng/mL Reference Reference
Q2: 2.7–5.7 ng/mL –32.97 (–63.94, 23.37) –24.42 (–55.51, 28.40)
Q3: 5.8–19.0 ng/mL –39.95 (–61.71, –5.82) –36.87 (–60.94, 2.02)
Q4: > 19.0 ng/mL –10.42 (–41.73, 39.10) –9.52 (–39.35, 33.64)
p-Trendc 0.04 0.08
Female children
Q1: ≤ 2.3 ng/mL Reference Reference
Q2: 2.4–3.9 ng/mL –11.31 (–28.82, 11.63) 22.14 (–34.30, 2.02)
Q3: 4.0–15.3 ng/mL –32.97 (–52.29, –4.88) –35.60 (–58.10, –1.00)
Q4: > 15.3 ng/ mL –9.52 (–36.87, 28.40) –17.30 (–56.83, 60.00)
p-Trendc 0.11 0.06
Female adolescents
Q1: ≤ 2.5 ng/mL Reference Reference
Q2: 2.6–7.3 ng/mL –2.96 (–24.42, 24.61) –3.92 (–27.39, 25.86)
Q3: 7.4–31.6 ng/mL –4.88 (–30.93, 32.31) –12.19 (–37.50, 24.61)
Q4: > 31.6 ng/mL –11.31 (–34.30, 20.92) –10.42 (–34.30, 22.14)
p-Trendc 0.69 0.88