Serum Testosterone Concentrations and Urinary Bisphenol A, Benzophenone-3, Triclosan, and Paraben Levels in Male and Female Children and Adolescents: NHANES 2011–2012

http://dx.doi.org/10.1289/EHP150



Table 5. Percent differences (95% CI) in serum total testosterone by quartiles of ∑PAR exposure, National Health and Nutrition Examination Survey, 2011–2012.
∑PAR exposure Model 1a Model 2b
aAdjusted for age, race/ethnicity, serum cotinine, urinary creatinine, total cholesterol, income, obesity, season of collection, time of venipuncture, and physical activity (for adolescents only).
bAdjusted for model 1 covariates plus natural log–transformed BP-3, BPA, and TCS.
cp-Value for exposure quartiles modeled as an ordinal variable using integer values.
Male children
Q1: ≤ 4.4 ng/mL Reference Reference
Q2: 4.5–10.1 ng/mL 44.77 (–21.34, 169.12) 43.33 (–17.30, 148.43)
Q3: 10.2–40.0 ng/mL –15.63 (–46.74, 32.31) –14.79 (–42.88, 28.40)
Q4: > 40.0 ng/mL 10.52 (–37.50, 95.42) 16.18 (–36.24, 113.83)
p-Trendc 0.22 0.29
Male adolescents
Q1: ≤ 4.9 ng/mL Reference Reference
Q2: 5.0–10.2 ng/mL –22.12 (–55.96, 39.10) –13.06 (–51.36, 53.73)
Q3: 10.3–61.5 ng/mL –16.47 (–45.66, 27.12) –3.92 (–32.29, 36.34)
Q4: > 61.5 ng/mL –23.66 (–51.32, 18.53) –14.79 (–48.31, 41.91)
p-Trendc 0.49 0.82
Female children
Q1: ≤ 11.3 ng/mL Reference Reference
Q2: 11.4–22.7 ng/mL 13.88 (–12.19, 47.70) 19.72 (–12.19, 63.23)
Q3: 22.8–76.8 ng/mL 12.55 (–21.34, 50.68) 18.53 (–13.06, 63.23)
Q4: > 76.8 ng/ mL 31.00 (–4.88, 82.21) 53.73 (–18.13, 191.54)
p-Trendc 0.39 0.11
Female adolescents
Q1: ≤ 15.5 ng/mL Reference Reference
Q2: 15.6–66.6 ng/mL –8.61 (–34.95, 29.69) –5.82 (–32.29, 31.00)
Q3: 66.7–297.9 ng/mL –21.34 (–43.45, 8.33) –24.42 (–44.57, 3.05)
Q4: > 297.9 ng/mL 3.05 (–29.53, 52.20) 4.08 (–25.92, 47.70)
p-Trendc 0.11 0.02