Statistical Approaches for Assessing Health Effects of Environmental Chemical Mixtures in Epidemiology: Lessons from an Innovative Workshop

http://dx.doi.org/10.1289/EHP547



Table 1. Examples of approaches presented at the NIEHS workshop “Statistical Approaches for Assessing Health Effects of Environmental Chemical Mixtures in Epidemiology Studies.”
Method Category
Single chemical analysis Classic linear regression (ordinary least squares)
Multiple regression Classic linear regression (ordinary least squares)
Visualization, structural equation modeling (SEM), and principal component analysis (PCA) Classification and prediction
Informed sparse PCA and segmented regression Classification and prediction
Bayesian g-formula Classification and prediction
PCA Classification and prediction
Classification and regression trees (CART) Classification and prediction
Bayesian profile regression Classification and prediction
Random forest Classification and prediction
Multivariate adaptive regression splines (MARS) Classification and prediction
Bayesian non-parametric regression Classification and prediction
Bayesian additive regression trees (BART) and negative sparse PCA (NSPCA) Classification and prediction
Conformal predictions Classification and prediction
Bayesian kernel machine regression (BKMR) Exposure–response surface estimation
Building Bayesian networks Exposure–response surface estimation
Exposure surface smoothing (ESS) Exposure–response surface estimation
Modes of action (results presented for Z = 0 strata) Other
Feasible solution algorithm (FSA) Other
Exploratory data analysis (EDA) Other
Novel approach and least-angle regression (LARS) Variable selection
Machine learning Variable selection
Two-step variable selection and least absolute shrinkage and selection operator (LASSO) Variable selection
Two-step shrinkage-based regression Variable selection
Factor mixture models Variable selection
Subset and bootstrap Variable selection
Variable selection regression (VSR) Variable selection
Bayesian estimation of weighted sum Variable shrinkage strategies
Shrinkage methods (LASSO/LARS) Variable shrinkage strategies
Weighted quantile sum regression (WQS) Variable shrinkage strategies
LASSO Variable shrinkage strategies