Prenatal Organophosphorus Pesticide Exposure and Child Neurodevelopment at 24 Months: An Analysis of Four Birth Cohorts

http://dx.doi.org/10.1289/ehp.1409474



Table 3. Association of creatinine-corrected log10 prenatal OP metabolite levels and 24-month MDI and PDI considering heterogeneity by center.
Model CHAMACOS
[β per 10-fold increase (95% CI)]a
HOME
[β per 10-fold increase (95% CI)]a
Columbia
[β per 10-fold increase (95% CI)]a
Mount Sinai
[β per 10-fold increase (95% CI)]a
Center-OP-interaction (p-value)a Pooled
[β per 10-fold increase (95% CI)]a
Pooled (extended model)
[β per 10-fold increase (95% CI)]b
∑DAP = ∑DEP + ∑DMP.
aModels were adjusted for maternal education, marital status, and age at delivery, alcohol use during pregnancy, child sex, Home environment score quartile, and breastfeeding at least 3 months after birth, and include metabolite × center interaction terms. Tests for interaction were calculated using F-tests with 3 degrees of freedom. bAdditionally adjusted for race/ethnicity, smoking and drug use during pregnancy.
24-month MDI n = 366 = 257 = 53 = 225 = 901 = 901 = 890
Log10 ∑DAP (nmol/gC) –4.17 (–7.00, –1.33) 0.97 (–1.82, 3.76) –0.79 (–4.17, 2.59) –1.14 (–3.12, 0.84) 0.09 –1.28 (–2.58, 0.03) –1.48 (–2.77, –0.19)
Log10 ∑DEP (nmol/gC) –1.40 (–4.12, 1.32) –1.10 (–3.42, 1.22) 0.11 (–2.88, 3.11) –0.22 (–1.85, 1.42) 0.81 –0.57 (–1.69, 0.54) –0.82 (–1.93, 0.28)
Log10 ∑DMP (nmol/gC) –3.64 (–5.97, –1.32) 0.73 (–1.59, 3.04) 0.13 (–2.33, 2.58) –0.80 (–2.52, 0.91) 0.05 –0.91 (–1.98, 0.16) –1.06 (–2.12, 0.00)
24-month PDI = 368 = 258 = 55 = 228 = 909 = 909 = 898
Log10 ∑DAP (nmol/gC) –1.35 (–4.10, 1.41) 1.09 (–1.63, 3.80) –0.39 (–3.67, 2.90) –0.27 (–2.17, 1.63) 0.67 –0.23 (–1.48, 1.03) –0.08 (–1.34, 1.18)
Log10 ∑DEP (nmol/gC) –0.91 (–3.54, 1.72) –0.32 (–2.57, 1.93) –0.35 (–3.13, 2.42) 0.52 (–1.03, 2.06) 0.79 –0.02 (–1.09, 1.04) 0.15 (–0.91, 1.22)
Log10 ∑DMP (nmol/gC) –1.29 (–3.56, 0.97) 0.83 (–1.41, 3.08) –0.42 (–2.79, 1.95) –0.45 (–2.11, 1.21) 0.63 –0.35 (–1.39, 0.68) –0.30 (–1.34, 0.73)