Prenatal Organophosphorus Pesticide Exposure and Child Neurodevelopment at 24 Months: An Analysis of Four Birth Cohorts

http://dx.doi.org/10.1289/ehp.1409474



Table 4. Association of creatinine-corrected log10 prenatal OP metabolite levels and 24-month MDI and PDI considering heterogeneity by race/ethnicity.
Model White
[β per 10-fold
increase (95% CI)]a
Black
[β per 10-fold
increase (95% CI)]a
Hispanic
[β per 10-fold
increase (95% CI)]a
Race/ethnicity-
OP interaction
(p-value)a
Pooled
[β per 10-fold
increase (95% CI)]b
∑DAP = ∑DEP + ∑DMP.
aModels were adjusted for maternal education, marital status and age at delivery, alcohol, drug use or smoking during pregnancy, child sex, quartiles of Home environment score, breastfeeding at least 3 months after birth, and birth before 2001, and include metabolite × race/ethnicity interaction terms. “Other” race/ethnicity was excluded due to small numbers. Tests for interaction were calculated using F-tests with 2 degrees of freedom. bPooled models include all race/ethnicity categories.
24-month MDI = 231 = 142 = 499 = 872 = 890
Log10 ∑DAP (nmol/gC) –0.29 (–2.89, 2.31) 0.49 (–2.07, 3.05) –2.91 (–4.71, –1.12) 0.06 –1.39 (–2.67, –0.10)
Log10 ∑DEP (nmol/gC) –1.46 (–3.62, 0.69) 0.09 (–2.15, 2.33) –1.00 (–2.57, 0.58) 0.60 –0.82 (–1.92, 0.29)
Log10 ∑DMP (nmol/gC) –0.21 (–2.39, 1.98) 1.10 (–0.94, 3.14) –2.34 (–3.77, –0.91) 0.02 –0.97 (–2.00, 0.07)
24-month PDI = 234 = 144 = 502 = 880 = 898
Log10 ∑DAP (nmol/gC) 2.34 (–0.21, 4.88) –0.47 (–2.97, 2.03) –0.41 (–2.18, 1.37) 0.18 0.26 (–1.00, 1.51)
Log10 ∑DEP (nmol/gC) 1.15 (–0.97, 3.27) –0.57 (–2.75, 1.62) 0.27 (–1.24, 1.78) 0.54 0.32 (–0.75, 1.40)
Log10 ∑DMP (nmol/gC) 1.62 (–0.52, 3.75) –0.12 (–2.15, 1.91) –0.53 (–1.95, 0.89) 0.25 0.06 (–0.96, 1.08)