Prenatal Organophosphorus Pesticide Exposure and Child Neurodevelopment at 24 Months: An Analysis of Four Birth Cohorts

http://dx.doi.org/10.1289/ehp.1409474



Table 5. Association of creatinine-corrected log10 prenatal OP metabolite levels and 24-month MDI according to PON1 genotype.
PON1 genotype Pooled Blacks Whites Hispanics
n Pooled β per 10-fold increase (95% CI)
log10 ∑DAP
(nmol/gC)a
Pooled β per 10-fold increase (95% CI)
log10 ∑DEP
(nmol/gC)a
Pooled β per 10-fold increase (95% CI)
log10 ∑DMP
(nmol/gC)a
n β per 10-fold
increase (95%CI)
log10 ∑DAP
(nmol/gC)b
n β per 10-fold increase (95% CI)
log10 ∑DAP
(nmol/gC)b
n β per 10-fold increase (95% CI)
log10 ∑DAP
(nmol/gC)b
∑DA= ∑DEP + ∑DMP.
aModels were adjusted for maternal race/ethnicity, maternal education, age at delivery and marital status, smoking, alcohol or drug use during pregnancy, child sex, quartile of Home environment score, breastfeeding at least 3 months after birth, and birth before 2001, and include metabolite × genotype interaction terms. Tests for interaction were calculated using F-tests with 2 degrees of freedom. bModels were adjusted for maternal education, age at delivery and marital status, smoking, alcohol or drug use during pregnancy, child sex, quartile of Home environment score, breastfeeding at least 3 months after birth, and birth prior to 2001, and include metabolite × genotype interaction terms. Tests for interaction were calculated using F-tests with 2 degrees of freedom.
–108 C/T 766 11 203 429
CC 280 –2.35 (–4.58, –0.12) –0.61 (–2.55, 1.33) –1.78 (–3.59, 0.03) 75 –0.50 (–4.33, 3.32) 58 –5.12 (–10.71, 0.48) 140 –2.31 (–5.95, 1.32)
CT 346 –0.12 (–2.22, 1.97) –0.24 (–2.17, 1.69) –0.45 (–2.17, 1.26) 37 3.47 (–1.74, 8.68) 96 –0.37 (–4.30, 3.56) 207 –1.55 (–4.43, 1.32)
TT (at risk) 140 –1.22 (–4.48, 2.03) –1.74 (–4.56, 1.07) 0.14 (–2.34, 2.61) 7 –1.38 (–15.23, 12.47) 49 5.35 (–0.41, 11.11) 82 –5.54 (–9.67, –1.40)
p-Interaction 0.36 0.68 0.39 0.45 0.04 0.29
Q192R 762 112 206 429
RR 229 0.51 (–1.98, 3.01) 2.09 (–0.14, 4.31) 0.08 (–2.16, 2.32) 56 3.52 (–0.21, 7.26) 17 9.71 (–4.79, 24.22) 103 –3.86 (–7.97, 0.25)
QR 354 –2.31 (–4.60, –0.02) –1.94 (–3.94, 0.07) –1.23 (–2.86, 0.39) 47 –3.16 (–9.63, 3.32) 74 –4.10 (–8.69, 0.48) 224 –1.87 (–4.84, 1.09)
QQ (at risk) 179 –1.74 (–4.22, 0.75) –1.93 (–4.10, 0.24) –1.13 (–3.27, 1.02) 9 –11.85 (–25.51, 1.80) 115 1.15 (–2.53, 4.84) 102 –3.19 (–6.70, 0.33)
p-Interaction 0.23 0.01 0.62 0.04 0.08 0.71