Polychlorinated Biphenyl and Organochlorine Pesticide Concentrations in Maternal Mid-Pregnancy Serum Samples: Association with Autism Spectrum Disorder and Intellectual Disability

http://dx.doi.org/10.1289/EHP277



Table 4. Prenatal PCB and OC Pesticide levels in association with ID risk (relative to GP controls).
Pesticide/quartile ID n Unadjusted OR (95% CI) AOR (95% CI)a
Abbreviations: ID, Intellectual disability without autism; other abbreviations as for Table 3.
aAdjusted as in Table 3.
PCBs
PCB28
Q1 46 1.0 (referent) 1.0
Q2 31 0.63 (0.37, 1.07) 0.68 (0.38, 1.22)
Q3 47 0.99 (0.61, 1.62) 1.01 (0.59, 1.75)
Q4 57 1.19 (0.74, 1.92) 1.00 (0.59, 1.68)
PCB99
Q1 39 1.0 1.0
Q2 52 1.48 (0.89, 2.45) 1.48 (0.85, 2.59)
Q3 41 0.97 (0.58, 1.63) 1.17 (0.66, 2.08)
Q4 28 0.66 (0.38, 1.16) 1.35 (0.68, 2.68)
PCB118
Q1 45 1.0 1.0
Q2 59 1.12 (0.69, 1.81) 1.44 (0.84, 2.48)
Q3 32 0.67 (0.39, 1.15) 0.88 (0.47, 1.65)
Q4 24 0.47 (0.27, 0.84) 0.87 (0.42, 1.81)
PCB138/158
Q1 50 1.0 1.0
Q2 62 1.24 (0.78, 1.97) 2.29 (1.32, 3.97)
Q3 27 0.53 (0.31, 0.91) 0.98 (0.52, 1.85)
Q4 37 0.73 (0.44, 1.20) 2.41 (1.18, 4.91)
PCB153
Q1 62 1.0 1.0
Q2 58 0.93 (0.59, 1.45) 1.55 (0.92, 2.62)
Q3 26 0.41 (0.24, 0.69) 0.77 (0.41, 1.44)
Q4 35 0.55 (0.34, 0.91) 1.76 (0.87, 3.57)
PCB170
Q1 60 1.0 1.0
Q2 39 0.65 (0.40, 1.07) 0.93 (0.53, 1.64)
Q3 31 0.48 (0.28, 0.80) 0.88 (0.47, 1.64)
Q4 30 0.48 (0.28, 0.80) 1.42 (0.69, 2.95)
PCB180
Q1 69 1.0 1.0
Q2 44 0.60 (0.38, 0.96) 0.92 (0.54, 1.57)
Q3 39 0.54 (0.34, 0.88) 0.97 (0.53, 1.74)
Q4 29 0.40 (0.24, 0.68) 1.35 (0.64, 2.81)
PCB187
Q1 55 1.0 1.0
Q2 39 0.72 (0.43, 1.18) 1.11 (0.63, 1.95)
Q3 38 0.66 (0.40, 1.09) 1.16 (0.63, 2.11)
Q4 28 0.49 (0.29, 0.84) 1.68 (0.79, 3.58)
PCB194
Q1 58 1.0 1.0
Q2 46 0.80 (0.50, 1.30) 1.05 (0.62, 1.80)
Q3 31 0.53 (0.31, 0.89) 0.81 (0.44, 1.49)
Q4 25 0.42 (0.24, 0.73) 1.20 (0.57, 2.50)
PCB196/203
Q1 52 1.0 1.0
Q2 49 1.04 (0.64, 1.69) 1.51 (0.87, 2.62)
Q3 32 0.56 (0.33, 0.95) 1.00 (0.53, 1.88)
Q4 27 0.50 (0.29, 0.87) 1.54 (0.71, 3.31)
PCB199
Q1 54 1.0 1.0
Q2 47 0.95 (0.58, 1.54) 1.27 (0.74, 2.18)
Q3 34 0.61 (0.36, 1.01) 0.98 (0.53, 1.80)
Q4 25 0.47 (0.27, 0.81) 1.36 (0.64, 2.92)
Sum of above PCBs
Q1 46 1.0 1.0
Q2 35 0.76 (0.45, 1.28) 1.00 (0.56, 1.78)
Q3 40 0.87 (0.52, 1.45) 1.21 (0.68, 2.15)
Q4 39 0.85 (0.51, 1.42) 1.43 (0.79, 2.58)
OC pesticides
p,p´-DDE
Q1 31 1.0 1.0
Q2 45 1.44 (0.85, 2.45) 1.42 (0.80, 2.54)
Q3 62 2.00 (1.20, 3.33) 1.89 (1.03, 3.44)
Q4 43 1.37 (0.80, 2.34) 1.15 (0.59, 2.24)
trans-Nonachlor
Q1 53 1.0 1.0
Q2 36 0.65 (0.39, 1.09) 0.67 (0.38, 1.17)
Q3 33 0.59 (0.35, 0.99) 0.98 (0.54, 1.79)
Q4 38 0.68 (0.41, 1.13) 0.97 (0.53, 1.77)