In Vitro Effects of Lead on Gene Expression in Neural Stem Cells and Associations between Up-regulated Genes and Cognitive Scores in Children

http://dx.doi.org/10.1289/EHP265



Table 1. Differential expression of human NSCs exposed to 1 μM Pb by RNA-seq.
HGNC name Gene description Fold change p-Value FDR
q-value
NRF2 target
Differential expression of triplicate pairs was performed in edgeR, and statistically significant differentially expressed transcripts were defined by > ± 0.2 log2-fold change and FDR-adjusted q-value < 0.05%. Annotation shows known NRF2 target genes according to a) Chorley et al. (2012), b) Wang et al. (2007), c) Cho et al. (2005), d) Lee et al. (2003), e) Li et al. (2002), f) Malhotra et al. (2010), and g) Thai et al. (2013).
F2RL2 Coagulation factor II (thrombin) receptor-like 2 2.35 1.05 × 10–19 4.62 × 10–16
OSGIN1 Oxidative stress induced growth inhibitor 1 2.29 8.21 × 10–12 2.06 × 10–8 a
LUCAT1 Lung cancer associated transcript 1 (nonprotein coding) 1.98 6.60 × 10–8 1.16 × 10–4 g
HMOX1 Heme oxygenase (decycling) 1 1.87 4.63 × 10–15 1.63 × 10–11 a,b,d,e
SPP1 Secreted phosphoprotein 1 1.82 3.27 × 10–22 1.92 × 10–18
NQO1 NAD(P)H dehydrogenase, quinone 1 1.8 2.24 × 10–33 3.93 × 10–29 a,b,c,f
EGF Epidermal growth factor 1.45 4.07 × 10–7 6.50 × 10–4
FTL Ferritin, light polypeptide 1.43 5.00 × 10–29 4.39 × 10–25 a,b
VGF VGF nerve growth factor inducible 1.39 8.65 × 10–13 2.53 × 10–9 b
TXNRD1 Thioredoxin reductase 1 1.38 1.22 × 10–9 2.68 × 10–6 a,b,f
SERPINE1 Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.36 1.53 × 10–6 1.92 × 10–3 b,c,f
SLC7A11 Solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 1.34 1.20 × 10–5 1.11 × 10–2 a
SLC7A8 Solute carrier family 7 (amino acid transporter light chain, L system), member 8 1.31 6.88 × 10–7 1.01 × 10–3
GREM1 Gremlin 1, DAN family BMP antagonist 1.28 5.19 × 10–6 5.07 × 10–3
PIR Pirin (iron-binding nuclear protein) 1.25 8.54 × 10–7 1.15 × 10–3 a
F13A1 Coagulation factor XIII, A1 polypeptide 1.24 5.05 × 10–5 3.55 × 10–2
B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 0.81 3.00 × 10–5 2.29 × 10–2
MIR503HG MIR503 host gene (non-protein coding) 0.73 2.14 × 10–5 1.79 × 10–2
DIO3OS DIO3 opposite strand/antisense RNA 0.68 3.35 × 10–6 3.47 × 10–3