Prenatal Exposure to Glycol Ethers and Neurocognitive Abilities in 6-Year-Old Children: The PELAGIE Cohort Study

http://dx.doi.org/10.1289/EHP39



Table 6. Associations between concentrations of glycol ether metabolite in mothers’ prenatal urine samples and the visuospatial skills (NEPSY) of their 6-year-old children.
Metabolite (mg/L) n NEPSY–Design Copying n NEPSY–Arrows
βcrude (95% CI) βadjusted (95% CI) βcrude (95% CI) βadjusted (95% CI)
Abbreviations: BAA, 2-butoxyacetic acid; EAA, ethoxyacetic acid; EEAA, ethoxyethoxyacetic acid; MAA, methoxyacetic acid; PhAA, phenoxyacetic acid. All adjusted models were adjusted for education, WAIS score, HOME score, creatinine concentration, and investigator who administered the neurocognitive test. Additional adjustments were made for breastfeeding (MAA), number of cigarettes smoked per day in the household at age 6 (MAA, EEAA), prepregnancy maternal body mass index (EAA, EEAA, BAA), maternal age (EAA), household renovation likely to involve exposure to organic solvents (EAA), alcohol consumption (EEAA), parity (BAA,) and fish consumption (BAA). For each NEPSY subtest, the mean scaled score was 10 and the standard deviation was 3 (minimum–maximum, 1–19).
MAA
≤ 0.043 68 Reference Reference 68 Reference Reference
> 0.043–0.081 67 0.02 (–0.08, 0.11) 0.02 (–0.08, 0.12) 67 0.02 (–0.08, 0.11) 0.02 (–0.08, 0.12)
> 0.081 69 0.05 (–0.05, 0.14) 0.04 (–0.06, 0.13) 69 0.03 (–0.07, 0.12) 0.01 (–0.08, 0.11)
Continuous (log) 204 0.02 (–0.01, 0.06) 0.02 (–0.02, 0.06) 204 0.01 (–0.03, 0.04) 0.01 (–0.03, 0.04)
EAA
≤ 0.011 68 Reference Reference 68 Reference Reference
> 0.011–0.021 67 0.04 (–0.05, 0.14) 0.03 (–0.07, 0.13) 67 0.01 (–0.09, 0.10) 0.01 (–0.10, 0.11)
> 0.021 69 –0.05 (–0.14, 0.05) –0.11 (–0.21, 0.00) 69 0.01 (–0.09, 0.10) –0.02 (–0.12, 0.09)
Continuous (log) 204 0.00 (–0.04, 0.04) –0.01 (–0.06, 0.03) 204 0.01 (–0.03, 0.05) 0.00 (–0.04, 0.05)
EEAA
≤ 0.016 68 Reference Reference 68 Reference Reference
> 0.016–0.050 66 –0.04 (–0.14, 0.05) –0.06 (–0.16, 0.04) 66 –0.07 (–0.17, 0.03) –0.08 (–0.18, 0.02)
> 0.050 70 –0.07 (–0.16, 0.03) –0.10 (–0.20, 0.01) 70 0.01 (–0.09, 0.10) 0.00 (–0.11, 0.10)
Continuous (log) 204 0.00 (–0.03, 0.02) –0.01 (–0.03, 0.01) 204 0.01 (–0.01, 0.03) 0.01 (–0.01, 0.03)
BAA
≤ 0.028 67 Reference Reference 67 Reference Reference
> 0.028–0.058 68 –0.01 (–0.10, 0.09) –0.01 (–0.11, 0.09) 68 0.00 (–0.09, 0.10) 0.00 (–0.10, 0.10)
> 0.058 69 –0.02 (–0.11, 0.08) –0.03 (–0.13, 0.06) 69 –0.03 (–0.13, 0.06) –0.05 (–0.15, 0.05)
Continuous (log) 204 0.02 (–0.02, 0.06) 0.01 (–0.04, 0.05) 204 0.00 (–0.04, 0.05) –0.01 (–0.05, 0.04)
PhAA
≤ 0.224 68 Reference Reference 68 Reference Reference
> 0.224–0.781 67 0.00 (–0.10, 0.10) 0.00 (–0.09, 0.10) 67 0.05 (–0.05, 0.14) 0.05 (–0.05, 0.15)
> 0.781 69 –0.01 (–0.11, 0.08) –0.01 (–0.11, 0.08) 69 0.03 (–0.07, 0.13) 0.04 (–0.06, 0.14)
Continuous (log) 204 0.00 (–0.02, 0.02) –0.01 (–0.03, 0.02) 204 0.01 (–0.01, 0.03) 0.01 (–0.02, 0.03)